Projects

  • NIEHS HHEAR HUB- North Carolina Human Health Exposure Analysis Resource (HHEAR) Hub. The North Carolina HHEAR Hub is conducting research to understand how exposures are related to states of health and wellness.
  • Hatch Project No. NC02619
  • Development of targeted metabolomics compound library and database (under continuous development and expansion) for:
    •  determining the extent to which metabolism alters bioactivity in human nutrition intervention trials
    • determining how phytochemical structure is influenced by food processing and human metabolism
  • Development of quantitative metabolomic MS/MS methodologies for establishing biosignatures of dietary phytochemical consumption.
    • MSn quantitative metabolomics methodologies provide fragmentation mass transitions and optimized UPLC-MS/MS parameters for quantifying the contribution of the plant metabolome to the human metabolome.
    • methods comprise optimized spectral signals for fragmentation profiling of over 500 phytochemicals and metabolites
    • methods have been utilized to interrogate over 5000 biospecimens derived from studies feeding various phytochemical-rich diets.
  • Ongoing development of dietary phytochemical MS/MS database for identifying previously unassigned spectral features in publically available metabolomics datasets; working with ADAP knowledge-base (UNC Charlotte) for metabolomics spectral assignment.
  • Foundation for Food and Agriculture Research (FFAR) – Seeding Solutions: Closing the gap in delivery of fruit and vegetable benefits. A project aimed at Improving Health through developing strategies for increasing the consumption of fruit and vegetable nutrients and non-nutrient phytochemicals